By Harry Salem,Sidney A. Katz
In over forty chapters, the booklet addresses 7 issues, starting with the validation and regulatory popularity of choices within the US, the united kingdom, and Western Europe. Then the publication covers tools in keeping with the mechanisms of eye inflammation on the ocular floor, dermal toxicity checking out, and assessing neurotoxicity. it is also a case examine within the use of choices to figure out the mechanism of sulfur mustard motion and discusses the position of transgenics and toxicokinetics within the improvement of other toxicity assessments. eventually the publication provides fresh techniques in choices, together with using archival facts, and in silico techniques.
Focusing at the technology and never the politics, substitute Toxicological tools concisely discusses the appliance of state of the art equipment and explores state-of-the-art examine with regards to constructing and validating choices to animal checking out. This booklet will profit toxicologists, beauty chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officials of their quest for utilising the 3Rs to using animals in toxicological trying out of drug applicants, chemical substances, and cosmetics.
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Alternative Toxicological Methods by Harry Salem,Sidney A. Katz