Alternative Toxicological Methods by Harry Salem,Sidney A. Katz PDF

By Harry Salem,Sidney A. Katz

ISBN-10: 084931528X

ISBN-13: 9780849315282

Bringing jointly the new and correct contributions of over one hundred twenty five scientists from undefined, executive, and academia in North the USA and Western Europe, replacement Toxicological equipment explores the improvement and validation of substitute, aid, and refinement possible choices (the 3Rs) to animal checking out. across the world well-known scientists current what has been finished so far in constructing applicable possible choices to conventional animal toxicological overview and supply possibly new initiatives.

In over forty chapters, the booklet addresses 7 issues, starting with the validation and regulatory popularity of choices within the US, the united kingdom, and Western Europe. Then the publication covers tools in keeping with the mechanisms of eye inflammation on the ocular floor, dermal toxicity checking out, and assessing neurotoxicity. it is also a case examine within the use of choices to figure out the mechanism of sulfur mustard motion and discusses the position of transgenics and toxicokinetics within the improvement of other toxicity assessments. eventually the publication provides fresh techniques in choices, together with using archival facts, and in silico techniques.

Focusing at the technology and never the politics, substitute Toxicological tools concisely discusses the appliance of state of the art equipment and explores state-of-the-art examine with regards to constructing and validating choices to animal checking out. This booklet will profit toxicologists, beauty chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officials of their quest for utilising the 3Rs to using animals in toxicological trying out of drug applicants, chemical substances, and cosmetics.

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Alternative Toxicological Methods by Harry Salem,Sidney A. Katz

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